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New phosphorylated derivatives of carboxymethylcellulose with osteogenic activity
Author(s) -
Leone Gemma,
Torricelli Paola,
Giardino Roberto,
Barbucci Rolando
Publication year - 2008
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.1041
Subject(s) - self healing hydrogels , swelling , polysaccharide , materials science , rheology , biomimetic synthesis , infrared spectroscopy , phosphate , osteocalcin , chemical engineering , nuclear chemistry , osteoblast , polymer chemistry , chemistry , organic chemistry , biochemistry , alkaline phosphatase , composite material , in vitro , engineering , enzyme
New phosphorylated derivatives of carboxymethylcellulose (CMC) and amidic CMC were realized using trisodium trimetaphosphate (STMP) as the phosphating agent. The new polysaccharides were characterized by infrared spectroscopy and elemental analysis. The characterized polysaccharides were then crosslinked and their rheological and swelling properties determined. The presence of phosphate groups made the three‐dimensional structures more compact and harder than the corresponding non‐phosphated hydrogels. Evaluation of the bioactivity of phosphorylated hydrogels toward osteoblast‐like cells (MG63) showed a significant increase in the osteocalcin production. Copyright © 2008 John Wiley & Sons, Ltd.