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Computational analysis of the influence of drusen growth on the morphology of RPE due to Age‐related Macular Degeneration
Author(s) -
Holla Vijaya,
Timothy Jithender J.,
Meschke Günther
Publication year - 2021
Publication title -
pamm
Language(s) - English
Resource type - Journals
ISSN - 1617-7061
DOI - 10.1002/pamm.202000298
Subject(s) - drusen , macular degeneration , choroid , retina , retinal , retinal pigment epithelium , ophthalmology , degeneration (medical) , bruch's membrane , biology , medicine , neuroscience
Age‐related macular degeneration (AMD) is a disease that affects the macular region of the outer retina. AMD is characterized by the presence of large extracellular debris called drusen between the Bruch's Membrane (BrM) in the choroid and the retinal pigment epithelium (RPE) in the outer retina. An important feature of AMD is the degenerative changes in the RPE and the photoreceptors that leads to the deterioration and loss of central vision. In this contribution, the effect of drusen size on the morphological changes in the RPE, BrM and photoreceptors are investigated using the cellular potts model (CPM) and machine learning. Numerical simulation of the influence of drusen growth and its effect on the morphology of the outer retinal layers of the macula is presented and the implications for AMD progression discussed.