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Towards a physiologically accurate ECG from numerical simulations: comparative analyses in a simplified tissue model
Author(s) -
Ogiermann Dennis,
Perotti Luigi E.,
Balzani Daniel
Publication year - 2021
Publication title -
pamm
Language(s) - English
Resource type - Journals
ISSN - 1617-7061
DOI - 10.1002/pamm.202000136
Subject(s) - computer science , focus (optics) , cardiac electrophysiology , wedge (geometry) , computational model , tensor (intrinsic definition) , biological tissue , simulation , biomedical engineering , electrophysiology , physics , neuroscience , mathematics , medicine , optics , biology , pure mathematics
Numerical simulations of the human heart can guide medical doctors and researchers only if properly validated. This work presents a computational framework to validate mathematical models of cardiac electrophysiology at the tissue level. Specifically, we focus on the transmural wedge experiment as proposed by Antzelevitch in 1996. This experimental setup is easily reproduced and allows to probe key modeling assumptions and components before organ level simulations are performed. Our results highlight the need to further investigate the conductivity tensor, which, by modifying wave propagation, will affect the ECG morphology at the organ level.