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On a Multi‐Scale and Multi‐Phase Model of Paracetamol‐induced Hepatotoxicity for Human Liver
Author(s) -
Lambers Lena,
Waschinsky Navina,
Ricken Tim
Publication year - 2018
Publication title -
pamm
Language(s) - English
Resource type - Journals
ISSN - 1617-7061
DOI - 10.1002/pamm.201800454
Subject(s) - detoxification (alternative medicine) , fatty liver , perfusion , liver disease , liver function , acetaminophen , blood flow , population , medicine , liver injury , disease , pharmacology , chemistry , physiology , pathology , environmental health , alternative medicine
More than 650 Million people worldwide suffer from a certain kind of liver disease. One of the most common disease is the non‐alcoholic fatty liver disease (NAFLD) which affects about 20‐30 % of the population in industrial countries. During a NAFLD fat is stored in liver cells causing tissue growth which impacts blood perfusion inside the liver. The liver is responsible for detoxification of drugs and toxins, e.g. the pain killer Paracetamol. However high dosages of toxic metabolites can harm the liver. The detoxification is perfusion‐dependent, due to the substances transported by the blood flow. To understand and predict the processes during a liver disease, we have developed a computational model using a multi‐scale and multi‐phase function‐perfusion approach basend on the Theory of Porous Media (TPM).