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Investigation of Tenocyte Migration Behaviour by Application of the Mechanobiological Concepts
Author(s) -
Dursun Gözde,
ÜrekYavas Dilmin,
Tohidnezhad Mersedeh,
Markert Bernd,
Stoffel Marcus
Publication year - 2018
Publication title -
pamm
Language(s) - English
Resource type - Journals
ISSN - 1617-7061
DOI - 10.1002/pamm.201800223
Subject(s) - tendon , materials science , ultimate tensile strength , collagen fibres , membrane , tissue engineering , collagen fiber , biomedical engineering , composite material , chemistry , engineering , anatomy , biology , biochemistry
Cell migration plays a key role in tendon wound healing. The migration characteristics of tenocytes can be motivated by external signals. Our study aims to examine and enhance the migration activities of tenocytes by the appliance of uniaxial mechanical stretch using a custom‐made tensile bioreactor. Uniaxial mechanical stretching is applied to tenocyte‐seeded silicone as well as collagen membranes, which possess different material characteristics. The collagen membranes are considered a promising candidate for tendon tissue engineering due to its biological properties.