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Bioreactor development for regenerative tissues of the locomotor system
Author(s) -
Stoffel Marcus,
Dursun Gözde,
Nachtsheim Julia,
FuhrmannNelles Nadine,
Markert Bernd
Publication year - 2018
Publication title -
pamm
Language(s) - English
Resource type - Journals
ISSN - 1617-7061
DOI - 10.1002/pamm.201800108
Subject(s) - bioreactor , cartilage , biochemical engineering , regenerative medicine , articular cartilage , regeneration (biology) , tissue engineering , biomedical engineering , computer science , chemistry , biology , microbiology and biotechnology , engineering , anatomy , stem cell , osteoarthritis , pathology , medicine , alternative medicine , organic chemistry
In biomedical engineering it is an important challenge to predict the mechanical behaviour of living biological tissues under dynamic loading conditions. As a basis for theoretical models, experimental set‐ups are necessary to trace evolutive processes, such as remodelling and growth, in biological materials. However, in order to mimic in‐vivo situations most realistically, in‐vitro bioreactor systems with physiologically enhanced loading conditions have to be developed. The present study deals with a set of bioreactor systems covering a wide range of applications for investigating remodelling behaviour of biological tissues, such as cartilage replacement materials in knee joints, tendons, and intervertebral discs.