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Remodeling of soft tissues due to cell activity
Author(s) -
Yi JeongHun,
Stoffel Marcus,
Weichert Dieter,
Rath Björn,
Markert Bernd
Publication year - 2014
Publication title -
pamm
Language(s) - English
Resource type - Journals
ISSN - 1617-7061
DOI - 10.1002/pamm.201410041
Subject(s) - stiffness , chemistry , cell , biophysics , cartilage , materials science , anatomy , biochemistry , composite material , biology
The continuum mechanical modeling of collagenous biological tissues is of interest in the field of biomedical engineering. Particularly, the change of material properties as a result of cell activity is of great interest, as chondrocyte (cartilage cell) implantation yields significant functional improvement. The aim of the contribution is to present the remodeling phenomenon of a cellular material due to cell activity, which results in synthesis of collagen type‐II fibers. For the experimental study, cellular condensed gel is mechanically stimulated in a bioreactor for four weeks. The change of the stiffness of the gel is measured in a compression test. The remodeling process is theoretically derived by an appropriate evolution law in the framework of continuum mechanics. (© 2014 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)