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Experimental and numerical investigations on engineering tissue enhanced by mechanical stimulation
Author(s) -
Yi JeongHun,
Stoffel Marcus,
Weichert Dieter,
Nebelung Sven,
Rath Björn
Publication year - 2011
Publication title -
pamm
Language(s) - English
Resource type - Journals
ISSN - 1617-7061
DOI - 10.1002/pamm.201110037
Subject(s) - stiffness , tissue engineering , bioreactor , stimulation , type i collagen , seeding , chemistry , biophysics , biomedical engineering , cell , compression (physics) , materials science , chemical engineering , composite material , engineering , biochemistry , thermodynamics , physics , medicine , biology , organic chemistry
The aim of the paper is to investigate the remodeling phenomenon of a cell‐seeded material (collagen type‐I) due to collagen type‐II newly synthesized by the cells. For the experiments, a cell‐seeded condensed collagen gel is mechanically stimulated in a bioreactor for four weeks. The remodeled stiffness of the cell‐seeded gel is measured by a compression test and is explained with an evolution law. (© 2011 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)