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A Microscopic model for a cell‐seeded material
Author(s) -
Yi Jeong Hun,
Stoffel Marcus,
Weichert Dieter,
Gavenis Karsten,
MüllerRath Ralf
Publication year - 2010
Publication title -
pamm
Language(s) - English
Resource type - Journals
ISSN - 1617-7061
DOI - 10.1002/pamm.201010043
Subject(s) - helmholtz free energy , fiber , deformation (meteorology) , constitutive equation , mechanics , energy balance , materials science , function (biology) , composite material , thermodynamics , physics , finite element method , evolutionary biology , biology
The aim of the present paper is to account for the growth of fiber which is observed in a cell‐seeded material stimulated in a bioreactor. For this purpose, the change of mass is considered in the balance laws, and the deformation energy is assumed to be a function of varying mass and the Helmholtz free‐energy. Fiber growth at the microscopic level causes a macroscopic change of the material's mechanical properties. The study is a first approach towards a micromechanical model accounting for remodelling in cartilage replacement materials. In so doing, constitutive equations for renewable soft tissues are proposed. (© 2010 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)