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An Analysis of Drug Dissolution Rates in the USP 24 Type 2 Apparatus
Author(s) -
McDonnell David,
Redmond Brendan,
D'Arcy Deirdre M,
Healy Anne Marie,
Corrigan Owen I
Publication year - 2009
Publication title -
pamm
Language(s) - English
Resource type - Journals
ISSN - 1617-7061
DOI - 10.1002/pamm.200910314
Subject(s) - dissolution , mass transfer , boundary layer , type (biology) , boundary (topology) , dissolution testing , drug , chemistry , chemical engineering , materials science , analytical chemistry (journal) , chromatography , thermodynamics , physics , engineering , mathematics , pharmacology , mathematical analysis , geology , medicine , paleontology , biopharmaceutics classification system
This paper applies boundary layer theory to the process of drug dissolution in the USP 24, Type 2 Apparatus. The mass transfer rate from the top flat surface of a compact in various positions within the device is evaluated by means of a Pohlhausen integral method. (© 2009 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)