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3D modelling of arterial growth for adaptation to hypertension — the influence of transmural changes in the mechanical environment
Author(s) -
Schmid Holger,
Watton Paul,
Röhrle Oliver,
Wang Yikun,
Itskov Mikhail
Publication year - 2009
Publication title -
pamm
Language(s) - English
Resource type - Journals
ISSN - 1617-7061
DOI - 10.1002/pamm.200910019
Subject(s) - mechanobiology , adaptation (eye) , arterial wall , computer science , cardiology , medicine , neuroscience , biology , anatomy
Many phenomenological models of cerebral aneurysm formation have been proposed. Such studies have focused on modeling the structural adaption of the arterial wall. However, further development is required to accurately represent the underlying mechanobiology during growth and remodeling processes. Here, we present a 3D computational model that incorporates transmurally heterogeneous material concentrations. This is a critical step toward more realistic models for growth and adaptation. (© 2009 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)