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Thermofluiddynamics in liquid media during biotechnological processes under high pressure
Author(s) -
Rauh C.,
Delgado A.
Publication year - 2008
Publication title -
pamm
Language(s) - English
Resource type - Journals
ISSN - 1617-7061
DOI - 10.1002/pamm.200810663
Subject(s) - momentum (technical analysis) , mass transport , scalar (mathematics) , chemistry , transport phenomena , process (computing) , chemical reaction , chemical process , biochemical engineering , thermodynamics , process engineering , mechanics , chemical engineering , physics , computer science , engineering , organic chemistry , mathematics , geometry , finance , economics , operating system
In bio/ chemical engineering high pressure (HP) processing up to several GPa represents a novel technique to selectively influence (bio–)chemical reactions resulting from temperature and pressure sensitivities differing between the occuring reactions. Therefore, thermofluiddynamical effects leading to inhomogeneous process conditions (pressure, temperature) show an important influence on the process results. To predict and improve mass, momentum and energy transport within the HP vessel and the impact on desired chemical reactions spatiotemporal numerical simulations are a useful tool in process analysis and design. The present contribution deals with mathematical modelling of the enzyme inactivation in HP processing of liquid biotechnological media. For the first time a transport equation for the scalar quantity “enzyme activity” is deduced. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)