Qualitative response of interaction networks: application to the validation of biological models | Zendy

Siegel Anne | Zendy; Guziolowski Carito | Zendy; Veber Philippe | Zendy; Radulescu Ovidiu | Zendy; Le Borgne Michel | Zendy

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Qualitative response of interaction networks: application to the validation of biological models

Author(s) -

Siegel Anne,

Guziolowski Carito,

Veber Philippe,

Radulescu Ovidiu,

Le Borgne Michel

Publication year - 2007

Publication title -

pamm

Language(s) - English

Resource type - Journals

ISSN - 1617-7061

DOI - 10.1002/pamm.200700379

Subject(s) - qualitative analysis , biological network , computer science , complex system , biological system , qualitative research , mathematics , artificial intelligence , biology , sociology , social science , combinatorics

We advocate the use of qualitative models for the analysis of shift equilibria in large biological systems. We present a mathematical method, allowing qualitative predictions to be made of the behaviour of a biological system. These predictions are not dependent on specific values of the kinetic constants. We show how these methods can be used to improve understanding of a complex regulatory system. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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