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Qualitative response of interaction networks: application to the validation of biological models
Author(s) -
Siegel Anne,
Guziolowski Carito,
Veber Philippe,
Radulescu Ovidiu,
Le Borgne Michel
Publication year - 2007
Publication title -
pamm
Language(s) - English
Resource type - Journals
ISSN - 1617-7061
DOI - 10.1002/pamm.200700379
Subject(s) - qualitative analysis , biological network , computer science , complex system , biological system , qualitative research , mathematics , artificial intelligence , biology , sociology , social science , combinatorics
We advocate the use of qualitative models for the analysis of shift equilibria in large biological systems. We present a mathematical method, allowing qualitative predictions to be made of the behaviour of a biological system. These predictions are not dependent on specific values of the kinetic constants. We show how these methods can be used to improve understanding of a complex regulatory system. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)