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A model of breast carcinogenesis and recurrence after radiotherapy
Author(s) -
Enderling Heiko,
Anderson Alexander R.A.,
Chaplain Mark A.J.
Publication year - 2007
Publication title -
pamm
Language(s) - English
Resource type - Journals
ISSN - 1617-7061
DOI - 10.1002/pamm.200700362
Subject(s) - radiation therapy , breast cancer , adjuvant radiotherapy , medicine , oncology , carcinogenesis , adjuvant , stage (stratigraphy) , breast conserving surgery , cancer , biology , mastectomy , paleontology
Breast conserving surgery and adjuvant radiotherapy are the standard treatment of early stage breast cancer. We present simulations of a mathematical model of breast carcinogenesis and identify fields of mutated cells in the breast (formed during puberty or pregnancy) as a potential source of local recurrence after treatment with radiotherapy. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
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