Open AccessEffect of β3‐adrenergic receptor gene polymorphism and lifestyle on overweight Japanese rural residents: A cross‐sectional study
Author(s) -
Hara Akinori,
Nguyen Phat Minh,
Tsujiguchi Hiromasa,
Nakamura Masaharu,
Yamada Yohei,
Suzuki Keita,
Suzuki Fumihiko,
Kasahara Tomoko,
Pham Oanh Kim,
Nakamura Haruki,
Kambayashi Yasuhiro,
Shimizu Yukari,
Nguyen Thao Thi Thu,
Miyagi Sakae,
Kan Takayuki,
Sato Takehiro,
Hosomichi Kazuyoshi,
Tajima Atsushi,
Nakamura Hiroyuki
Publication year - 2022
Publication title -
obesity science and practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.654
H-Index - 14
ISSN - 2055-2238
DOI - 10.1002/osp4.560
Subject(s) - medicine , obesity , overweight , body mass index , waist , demography , logistic regression , polymorphism (computer science) , cohort , gene polymorphism , genotype , population , beta 3 adrenergic receptor , cross sectional study , body fat percentage , gerontology , genetics , environmental health , gene , biology , adrenergic receptor , receptor , pathology , sociology
Objectives The β3‐adrenergic receptor ( ADRB3 ) gene polymorphism has been implicated in obesity. Therefore, the contribution of ADRB3 Trp64Arg polymorphism to obesity‐related indicators was investigated, taking into account the lifestyle‐related factors in a Japanese rural population. Methods A total of 600 Japanese adults aged ≥40 years in a population‐based cohort study were analyzed. The ADRB3 polymorphism was determined using peripheral blood samples. Associations between genotype and body mass index (BMI), waist circumference (WC), and body fat (BF) percentage were examined, adjusting for lifestyle‐related factors, including daily nutrient intake. Results The frequency of Arg64 allele carriers was 36%. There was no significant difference in BMI, WC, or BF between the groups with or without the Trp64Arg polymorphism. Multivariable logistic regression analysis showed that the Trp64Arg polymorphism was not associated with these three indicators, but lifestyle factors including physical inactivity, higher energy and sodium consumption, and less animal protein intake were significantly related to increased WC and BF percentages. Conclusions The Trp64Arg polymorphism of ADRB3 gene did not contribute to increased BMI, WC, or BF. However, lifestyle‐related factors impacted these indicators in middle‐aged and older Japanese individuals living in rural areas.