Open AccessAge increases MCP‐1 level in association with bariatric surgery operating time and metabolic risk severity
Author(s) -
Malin S. K.,
Kaplan J. L.,
Meng L.,
Garmey J. C.,
Kirby J. L.,
Taylor A. M.,
Hallowell P. T.,
McNamara C. A.
Publication year - 2017
Publication title -
obesity science and practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.654
H-Index - 14
ISSN - 2055-2238
DOI - 10.1002/osp4.105
Subject(s) - medicine , body mass index , inflammation , diabetes mellitus , adipose tissue , obesity , metabolic syndrome , insulin , gastroenterology , surgery , endocrinology
Summary Objective Assess the role of inflammation on operating time in younger vs. older bariatric surgery patients. Methods Fifty‐five younger (F: 46, Age: 34.9 ± 4.0 years, body mass index [BMI]: 48.2 ± 1.0 kg m −2 ) and 48 older (F: 34, Age: 57.0 ± 5.1 years, BMI: 46.8 ± 1.0 kg m −2 ) adults were studied prior to surgery. Blood pressure, glycaemic control (fasting glucose/insulin, HbA 1c ), lipids (high‐density lipoprotein and triglycerides) and inflammation (monocyte chemoattractant protein‐1 [MCP‐1]) were assessed. Metabolic risk severity z ‐scores were calculated from clinical outcomes. Omental adipose biopsies were collected at surgery for MCP‐1 protein analysis. Operating time was used to characterize surgical difficulty. Results Older vs. younger adults had higher HbA 1c ( P = 0.03). There was no difference in BMI, lipids, metabolic risk severity or insulin between groups, but operating time was longer in older vs. younger individuals ( P = 0.04). Circulating MCP‐1 was also elevated in older vs. younger adults ( P = 0.04) independent of HbA 1c , although this was not explained by omental fat. Nevertheless, serum MCP‐1 was associated with increased metabolic risk severity ( R = 0.27, P = 0.01). In addition, operating time was linked to HbA 1c ( R = 0.30, P = 0.01) and omental MCP‐1 protein ( R = 0.31, P < 0.01). Conclusions MCP‐1 is associated with longer operating time and increased metabolic risk severity in older bariatric patients independent of glycaemic control. Pre‐operative treatment of inflammation may be required to enhance surgery effectiveness.