Open AccessTotal Synthesis of Resveratrone and iso ‐Resveratrone
Author(s) -
Fritsch Stefan,
Aldemir Nazli,
Balszuweit Jan,
Bojaryn Kevin,
Voskuhl Jens,
Hirschhäuser Christoph
Publication year - 2022
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.202200098
Subject(s) - epoxide , azide , derivative (finance) , chemistry , combinatorial chemistry , total synthesis , absorption (acoustics) , organic chemistry , materials science , catalysis , financial economics , economics , composite material
Abstract The first total synthesis of resveratrone and iso ‐resveratrone based on an epoxide olefination approach is described. The pivotal reaction proceeds by insertion of the lithiated epoxide into a boronic ester and subsequent syn ‐elimination. Resveratrone has been described to have remarkable photophysical properties, including two‐photon absorption. Therefore, an azide derivative has been prepared to allow for use as a biological label.