Open AccessAn Efficient Method for the Preparation of Sulfonamides from Sodium Sulfinates and Amines
Author(s) -
Tian Haiying,
Li Ruiyan,
Guo Fang,
Chen Xiuling
Publication year - 2022
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.202200097
Subject(s) - sulfonamide , chemistry , reductive amination , environmentally friendly , sodium , combinatorial chemistry , organic chemistry , biology , catalysis , ecology
Sulfonamides have a special role on medicine due to their broad biological activities, as bacterial infections, diabetes mellitus, oedema, hypertension prevention and treatment. In addition, sulfonamides are also useful in herbicides and pesticides. Herein, we communicate an efficient strategy for the preparation of sulfonamides via NH 4 I‐mediated amination of sodium sulfinates. This new method provides a general and environmentally friendly access to sulfonamide compounds and tolerates a wide range of functional groups.