An Efficient Method for the Preparation of Sulfonamides from Sodium Sulfinates and Amines | Zendy

Tian Haiying | Zendy; Li Ruiyan | Zendy; Guo Fang | Zendy; Chen Xiuling | Zendy

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An Efficient Method for the Preparation of Sulfonamides from Sodium Sulfinates and Amines

Author(s) -

Tian Haiying,

Li Ruiyan,

Guo Fang,

Chen Xiuling

Publication year - 2022

Publication title -

chemistryopen

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.644

H-Index - 29

ISSN - 2191-1363

DOI - 10.1002/open.202200097

Subject(s) - sulfonamide , chemistry , combinatorial chemistry , reductive amination , sodium , amination , environmentally friendly , organic chemistry , biology , catalysis , ecology

Sulfonamides have a special role on medicine due to their broad biological activities, as bacterial infections, diabetes mellitus, oedema, hypertension prevention and treatment. In addition, sulfonamides are also useful in herbicides and pesticides. Herein, we communicate an efficient strategy for the preparation of sulfonamides via NH 4 I‐mediated amination of sodium sulfinates. This new method provides a general and environmentally friendly access to sulfonamide compounds and tolerates a wide range of functional groups.

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