Open AccessBeyond Kolbe and Hofer–Moest: Electrochemical Synthesis of Carboxylic Anhydrides from Carboxylic Acids
Author(s) -
Häring Andreas P.,
Pollok Dennis,
Strücker Benjamin R.,
Kilian Vincent,
Schneider Johannes,
Waldvogel Siegfried R.
Publication year - 2022
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.202200059
Subject(s) - reagent , chemistry , carboxylic acid , electrochemistry , electrolysis , combinatorial chemistry , substrate (aquarium) , organic chemistry , selectivity , nanotechnology , materials science , electrode , catalysis , oceanography , electrolyte , geology
Herein we report a conceptually new non‐decarboxylative electrolysis of carboxylic acids to obtain their corresponding anhydrides as highly valuable reagents in organic synthesis. All carbon atoms of the starting material are preserved in the product in an overall redox‐neutral reaction. In a broad substrate scope of carboxylic acids the anhydrides are generated with high selectivity, which demonstrates the versatility of the developed method. Beneficially, no dehydrating reagents are required in comparison to conventional methods and the synthesis is based on uncritical starting materials using graphite and stainless steel as very inexpensive and eco‐friendly electrode materials.