Open AccessExploring Helical Folding in Oligomers of Cyclopentane‐Based ϵ‐Amino Acids: A Computational Study
Author(s) -
Park Hae Sook,
Kang Young Kee
Publication year - 2022
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.202200035
Subject(s) - random hexamer , cyclopentane , chloroform , chemistry , folding (dsp implementation) , stereochemistry , crystallography , computational chemistry , organic chemistry , electrical engineering , engineering
Invited for this month's cover picture is the group of Young Kee Kang at Chungbuk National University (Republic of Korea). The cover picture shows the preferred conformation of the hexamer of ϵ‐amino acid Amc 5 a with a cyclopentane substituent in the backbone investigated using DFT methods in chloroform and water. The Amc 5 a hexamer adopted a stable left‐handed conformation with a rise of 4.8 Å per turn both in chloroform and water. However, the hexamer of Ampa (an analogue of Amc 5 a with replacing cyclopentane by pyrrolidine) adopted different conformations in chloroform and in water. Read the full text of their Research Article at 10.1002/open.202100253.