Open AccessFeO(OH)@C‐Catalyzed Selective Hydrazine Substitution of p ‐Nitro‐Aryl Fluorides and their Application for the Synthesis of Phthalazinones
Author(s) -
Li Dingzhong,
Zhang Wensheng,
Zhu Longzhi,
Yin ShuangFeng,
Kambe Nobuaki,
Qiu Renhua
Publication year - 2022
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.202200023
Subject(s) - hydrazine (antidepressant) , nitro , chemistry , aryl , catalysis , yield (engineering) , nitro compound , selectivity , medicinal chemistry , organic chemistry , combinatorial chemistry , materials science , alkyl , chromatography , metallurgy
An efficient hydrazine substitution of p ‐nitro‐aryl fluorides with hydrazine hydrates catalyzed by FeO(OH)@C nanoparticles is described. This hydrazine substitutions of p ‐nitro‐aryl fluorides bearing electron‐withdrawing groups proceeded efficiently with high yield and selectivity. Similarly, hydrogenations of p ‐nitro‐aryl fluorides containing electron‐donating groups also smoothly proceeded under mild conditions. Furthermore, with these prepared aryl hydrazines, some phthalazinones, interesting as potential structures for pharmaceuticals, have successfully been synthesized in high yields.