Open AccessNanoscale Biocompatible Structures Generated from Fluorinated Tripodal Phenylenes on Gold Nanoprisms
Author(s) -
GarcíaCastro Miguel,
Moscoso Ana,
Sarabia Francisco,
LópezRomero Juan Manuel,
ContrerasCáceres Rafael,
Díaz Amelia
Publication year - 2022
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.202200007
Subject(s) - monolayer , nanotechnology , self assembled monolayer , tripod (photography) , chemistry , transmission electron microscopy , colloidal gold , self assembly , nanoparticle , chemical engineering , chemical modification , scanning electron microscope , biosensor , nanoscopic scale , materials science , polymer chemistry , physics , engineering , optics , composite material
Modification of gold substrates with a stable, uniform and ultrathin layer of biocompatible materials is of tremendous interest for the development of bio‐devices. We present the fabrication of hybrid systems consisting of triangular prism gold nanoparticles (Au@NTPs) covalently covered with tripod‐shaped oligo( p ‐phenylenes) featuring trifluoromethyl groups. Their synthesis is accomplished using a biphenyl boronic ester as the key compound. Au@NTPs were prepared through a seedless procedure using 3‐butenoic acid and benzyldimethyl ammonium chloride, and modified with aminothiol groups. Coverage of this amine‐modified gold substrate with a self‐assembled monolayer (SAM) of tripod‐shaped molecules is carried out in ethanolic solution. The hybrid system avoids up to 70 % of protein corona formation, and allows unspecific attachment for bulky adsorbates, providing an optimal biosensing platform. Chemical composition and morphology are analyzed by transmission electron microscopy (TEM), UV‐visible spectroscopy and field emission scanning electron microscopy (FESEM).