Open AccessAn Electrochemical Way to Generate Amphiphiles from Hydrazones for the Synthesis of 1,2,4‐Triazole Scaffold Cyclic Compounds
Author(s) -
Li Wangyu,
Xiong Mingteng,
Liang Xiao,
Wang Dungai,
Zhu Heping,
Pan Yuanjiang
Publication year - 2022
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.202100268
Subject(s) - combinatorial chemistry , amphiphile , anode , electrochemistry , chemistry , triazole , scaffold , transformation (genetics) , 1,2,4 triazole , nanotechnology , organic chemistry , materials science , computer science , electrode , polymer , copolymer , biochemistry , database , gene
An electro‐oxidative cyclization pathway in which hydrazones are selected as starting materials to generate amphiphiles by reacting with benzylamines and benzamides was reported. This strategy successfully prepared a series of 1,2,4‐triazoles in satisfactory yields. Moreover, the use of cheap stainless steel as the anode, the feasibility to conduct the transformation as a one‐pot reaction and the proof that scaling‐up these reactions is possible make this transformation attractive for potential application in industry.