Open AccessPreparation, Antibacterial Activity, and Catalytic Application of Magnetic Graphene Oxide‐Fucoidan in the Synthesis of 1,4‐Dihydropyridines and Polyhydroquinolines
Author(s) -
Nosrati Aliakbar,
Amirnejat Sara,
Javanshir Shahrzad
Publication year - 2021
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.202100221
Subject(s) - fucoidan , thermogravimetric analysis , catalysis , graphene , nuclear chemistry , fourier transform infrared spectroscopy , raman spectroscopy , antibacterial activity , chemistry , scanning electron microscope , iron oxide nanoparticles , materials science , nanoparticle , chemical engineering , nanotechnology , organic chemistry , polysaccharide , bacteria , physics , optics , biology , engineering , composite material , genetics
Polymer‐coated magnetic nanoparticles are emerging as a useful tool for a variety of applications, including catalysis. In the present study, fucoidan‐coated magnetic graphene oxide was synthesized using a natural sulfated polysaccharide. The prepared BaFe 12 O 19 @GO@Fu (Fu=fucoidan, GO=graphene oxide) was characterized using Fourier‐transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy‐dispersive X‐ray (EDX) analysis, vibrating sample magnetometry (VSM), thermogravimetric analysis (TGA), Raman spectroscopy, and X‐ray diffraction (XRD). The catalytic proficiency of BaFe 12 O 19 @GO@Fu was investigated in the synthesis of 1,4‐dihydropyridine and polyhydroquinoline derivatives. Excellent turnover numbers (TON) and turnover frequencies (TOF) (6330 and 25320 h −1 ) testify to the high efficiency of the catalyst. Moreover, the antimicrobial activity of BaFe 12 O 19 @GO@Fu was evaluated against Escherichia coli (E. coli) , and Staphylococcus aureus ( S. aureus ) through the Agar well diffusion method, indicating that BaFe 12 O 19 @GO@Fu has antibacterial activity against S. aureus .