Open AccessAromatic Fluorination of Multiblock Amphiphile Enhances Its Incorporation into Lipid Bilayer Membranes
Author(s) -
Sasaki Ryo,
Sato Kohei,
Kinbara Kazushi
Publication year - 2020
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.201900374
Subject(s) - amphiphile , membrane , bilayer , chemistry , lipid bilayer , solvent , model lipid bilayer , aqueous solution , absorption (acoustics) , lipid bilayer phase behavior , organic chemistry , chemical engineering , materials science , biochemistry , copolymer , polymer , composite material , engineering
We designed multiblock amphiphiles AmF and AmH , which consist of perfluorinated and non‐fluorinated hydrophobic units, respectively. Absorption spectroscopy revealed that both amphiphiles are molecularly dispersed in organic solvent, while they form aggregates under aqueous conditions. Furthermore, we investigated whether AmF and AmH can be incorporated into DOPC lipid bilayer membranes, and found that the maximum concentration of AmF that can be incorporated into DOPC lipid bilayer membranes is 43 times higher than that of AmH .