Open AccessA Simple Near‐Infrared Fluorescent Probe for the Detection of Peroxynitrite
Author(s) -
Wu Luling,
Tian Xue,
Han HaiHao,
Wang Jie,
Groleau Robin R.,
Tosuwan Paramabhorn,
Wannalerse Boontana,
Sedgwick Adam C.,
Bull Steven D.,
He XiaoPeng,
James Tony D.
Publication year - 2019
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.201900301
Subject(s) - peroxynitrite , fluorescence , chemistry , hela , biophysics , reactive oxygen species , biochemistry , combinatorial chemistry , superoxide , biology , in vitro , physics , enzyme , quantum mechanics
Herein, we report the evaluation and synthesis of a reaction based fluorescent probe DCM‐Bpin for the detection of Peroxynitrite (ONOO−). DCM‐Bpin exhibits selective fluorescence off‐on response for ONOO − over other reactive oxygen species, including H 2 O 2 . Moreover, DCM‐Bpin is biocompatible and has been used to visualize exogenous ONOO − in HeLa cells.