A Simple Near‐Infrared Fluorescent Probe for the Detection of Peroxynitrite | Zendy

Wu Luling | Zendy; Tian Xue | Zendy; Han HaiHao | Zendy; Wang Jie | Zendy; Groleau Robin R. | Zendy; Tosuwan Paramabhorn | Zendy; Wannalerse Boontana | Zendy; Sedgwick Adam C. | Zendy; Bull Steven D. | Zendy; He XiaoPeng | Zendy; James Tony D. | Zendy

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A Simple Near‐Infrared Fluorescent Probe for the Detection of Peroxynitrite

Author(s) -

Wu Luling,

Tian Xue,

Han HaiHao,

Wang Jie,

Groleau Robin R.,

Tosuwan Paramabhorn,

Wannalerse Boontana,

Sedgwick Adam C.,

Bull Steven D.,

He XiaoPeng,

James Tony D.

Publication year - 2019

Publication title -

chemistryopen

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.644

H-Index - 29

ISSN - 2191-1363

DOI - 10.1002/open.201900301

Subject(s) - peroxynitrite , fluorescence , hela , chemistry , biophysics , combinatorial chemistry , biochemistry , biology , superoxide , in vitro , enzyme , physics , quantum mechanics

Herein, we report the evaluation and synthesis of a reaction based fluorescent probe DCM‐Bpin for the detection of Peroxynitrite (ONOO−). DCM‐Bpin exhibits selective fluorescence off‐on response for ONOO − over other reactive oxygen species, including H 2 O 2 . Moreover, DCM‐Bpin is biocompatible and has been used to visualize exogenous ONOO − in HeLa cells.

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