Open AccessGas/Liquid‐Phase Micro‐Flow Trifluoromethylation using Fluoroform: Trifluoromethylation of Aldehydes, Ketones, Chalcones, and N ‐Sulfinylimines
Author(s) -
Hirano Kazuki,
Gondo Satoshi,
Pungender,
Tokunaga Etsuko,
Shibata Norio
Publication year - 2019
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.201800286
Subject(s) - trifluoromethylation , chemistry , flow chemistry , trifluoromethyl , nucleophile , organic chemistry , combinatorial chemistry , catalysis , alkyl
A micro‐flow nucleophilic trifluoromethylation of carbonyl compounds using gaseous fluoroform was developed. This method also allows the first micro‐flow transformation of N ‐sulfinylimines into trifluoromethyl amines with excellent diastereoselectivity. To demonstrate the synthetic utility of this micro‐flow synthesis, the formal micro‐flow synthesis of Efavirenz is described.