Open AccessSynthesis and Characterization of Novel Fluoro‐glycosylated Porphyrins that can be Utilized as Theranostic Agents
Author(s) -
Arja Katriann,
Elgland Mathias,
Appelqvist Hanna,
Konradsson Peter,
Lindgren Mikael,
Nilsson K. Peter R.
Publication year - 2018
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.201800095
Subject(s) - porphyrin , photodynamic therapy , chemistry , combinatorial chemistry , surface modification , cancer cell , fluorescence , positron emission tomography , nanotechnology , cancer therapy , cancer , materials science , biochemistry , organic chemistry , medicine , physics , nuclear medicine , quantum mechanics
Invited for this month's cover picture is the group of Professor Peter Nilsson at the Department of Physics, Chemistry and Biology at Linköping University (Sweden). The cover picture shows a fluoro‐glycoporphyrin that selectively targets cancer cells. The selectivity towards cancer cells are afforded due to proper functionalization of the porphyrin scaffold with specific carbohydrates, and the cancer cells can be visualized because of the intrinsic fluorescence from the porphyrin. The molecule also exhibits properties for photodynamic therapy and the incorporation of fluorine, in the form of 2‐fluoro‐2‐deoxy glucose (FDG), offers the possibility to apply these compounds as 18F positron emission tomography (PET) tracers. Thus, fluoro‐glycoporphyrins display multimodal properties and can be employed as theranostic agents targeting cancer cells. Read the full text of their Full Paper at 10.1002/open.201800020 .