Open AccessPOxylated Dendrimer‐Based Nano‐in‐Micro Dry Powder Formulations for Inhalation Chemotherapy
Author(s) -
Restani Rita B.,
Pires Rita F.,
Tolmatcheva Anna,
Cabral Rita,
Baptista Pedro V.,
Fernandes Alexandra R.,
Casimiro Teresa,
Bonifácio Vasco D. B.,
AguiarRicardo Ana
Publication year - 2018
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.201800093
Subject(s) - paclitaxel , doxorubicin , chemistry , cytotoxicity , nanoparticle , supercritical fluid , chitosan , dendrimer , materials science , in vitro , chemotherapy , nanotechnology , organic chemistry , medicine , surgery , biochemistry
POxylated polyurea dendrimer (PURE G4 OOx 48 )‐based nanoparticles were loaded with paclitaxel (PTX) and doxorubicin (DOX) and micronized with chitosan (CHT) by using supercritical CO 2 ‐assisted spray drying (SASD). Respirable, biocompatible, and biodegradable dry powder formulations (DPFs) were produced to effectively transport and deliver the chemotherapeutics with a controlled rate to the deep lung. In vitro studies performed with the use of the lung adenocarcinoma cell line showed that DOX@PURE G4 OOx 48 nanoparticles were much more cytotoxic than the free drug. Additionally, the DPFs did not show higher cytotoxicity than the respective nanoparticles, and DOX‐DPFs showed a higher chemotherapeutic effect than PTX formulations in adenocarcinoma cells.