Open AccessCover Feature: Macromolecular Crowding May Significantly Affect the Performance of an MRI Contrast Agent: A 1 H NMR Spectroscopy, Microimaging, and Fast‐Field‐Cycling NMR Relaxometry Study (ChemistryOpen 4/2018)
Author(s) -
Cheng RenHao,
Chen JieMin,
Chen YuWen,
Cai Honghao,
Cui Xiaohong,
Hwang Dennis W.,
Chen Zhong,
Ding Shangwu
Publication year - 2018
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.201800033
Subject(s) - relaxometry , macromolecular crowding , macromolecule , paramagnetism , relaxation (psychology) , nuclear magnetic resonance , nuclear magnetic resonance spectroscopy , chemistry , mri contrast agent , contrast (vision) , site directed spin labeling , magnetic resonance imaging , feature (linguistics) , chemical physics , materials science , gadolinium , spin echo , electron paramagnetic resonance , computer science , physics , radiology , condensed matter physics , medicine , organic chemistry , artificial intelligence , biochemistry , linguistics , philosophy
The Cover Feature shows that macromolecular crowders PEG or BSA in an aqueous solution of a paramagnetic magnetic resonance imaging (MRI) contrast agent generally bring additional proton spin relaxation to the water molecules close to the paramagnetic ion and lead to contrast change in the MRI images. This highlights the importance of considering the effect of macromolecular crowding on the performance of MRI contrast agents and image analysis, as well as diagnosis in clinical and functional MRI. More information can be found in the Full Paper on page 288 in Issue 4, 2018 by R.‐H. Cheng et al. (DOI: 10.1002/open.201700192).