Open AccessFront Cover: Early‐Stage Incorporation Strategy for Regioselective Labeling of Peptides using the 2‐Cyanobenzothiazole/1,2‐Aminothiol Bioorthogonal Click Reaction (ChemistryOpen 3/2018)
Author(s) -
Chen KuoTing,
Ieritano Christian,
Seimbille Yann
Publication year - 2018
Publication title -
chemistryopen
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.201800017
Subject(s) - bioorthogonal chemistry , regioselectivity , cycloaddition , click chemistry , combinatorial chemistry , biocompatible material , chemistry , computer science , flexibility (engineering) , bioconjugation , nanotechnology , materials science , biomedical engineering , organic chemistry , mathematics , engineering , catalysis , statistics
The Front Cover shows an innovative methodology for the regioselective labeling of peptides. Early‐stage incorporation of a clickable handle during SPPS provides flexibility for the functionalization of peptide‐based targeting vectors. Once the click handle has been ideally positioned, an imaging probe is conjugated to the targeting vector by 2‐cyanobenzothiazole (CBT)/1,2‐aminothiol cycloaddition. This key reaction is as easy as just “one click”. The labeling reaction is rapid, biocompatible, orthogonal, and highly efficient. It offers a nearly ideal labeling strategy for peptides and a powerful tool for the development of novel imaging agents for biomedical applications. More information can be found in the Communication by K.‐T. Chen et al. on page 256 in Issue 3, 2018 (DOI: 10.1002/open.201700191).