Open AccessBack Cover: Deeper Insight into the Six‐Step Domino Reaction of Aldehydes with Malononitrile and Evaluation of Antiviral and Antimalarial Activities of the Obtained Bicyclic Products (ChemistryOpen 3/2017)
Author(s) -
Bock Christina M.,
Parameshwarappa Gangajji,
Bönisch Simon,
Bauer Walter,
Hutterer Corina,
Leidenberger Maria,
Friedrich Oliver,
Marschall Manfred,
Kappes Barbara,
Görling Andreas,
Tsogoeva Svetlana B.
Publication year - 2017
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.201700092
Subject(s) - domino , combinatorial chemistry , malononitrile , cascade reaction , cover (algebra) , domino effect , human immunodeficiency virus (hiv) , chemistry , computer science , organic chemistry , virology , biology , engineering , catalysis , physics , nuclear physics , mechanical engineering
The Back Cover picture highlights the easy generation of complex azabicyclic and carbobicyclic molecules from two simple compounds in a single operation through a highly efficient six‐step domino reaction. Within a multi‐step domino reaction, one transformation triggers the next, similar to a row of dominoes where one tile hits the next. The in vitro studies against the herpes virus and malaria reveal domino products as highly active compounds, outperforming the clinical reference drugs ganciclovir and chloroquine. More information can be found in the Full Paper by S. B. Tsogoeva and co‐workers on page 364 in Issue 3, 2017 ( 10.1002/open.201700005).