Open AccessMild Reductive Functionalization of Amides into N ‐Sulfonylformamidines
Author(s) -
Trillo Paz,
Slagbrand Tove,
Tinnis Fredrik,
Adolfsson Hans
Publication year - 2017
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.201700087
Subject(s) - surface modification , chemistry , molybdenum , catalysis , sulfonyl , combinatorial chemistry , organic chemistry , alkyl
The development of a protocol for the reductive functionalization of amides into N ‐sulfonylformamidines is reported. The one‐pot procedure is based on a mild catalytic reduction of tertiary amides into the corresponding enamines by the use of Mo(CO) 6 (molybdenum hexacarbonyl) and TMDS (1,1,3,3‐tetramethyldisiloxane). The formed enamines were allowed to react with sulfonyl azides to give the target compounds in moderate to good yields.