Open AccessTargeted Fluoro Positioning for the Discovery of a Potent and Highly Selective Matrix Metalloproteinase Inhibitor
Author(s) -
Fischer Thomas,
Riedl Rainer
Publication year - 2017
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.201700042
Subject(s) - matrix metalloproteinase , matrix metalloproteinase inhibitor , drug discovery , computational biology , combinatorial chemistry , small molecule , chemistry , stereochemistry , biochemistry , pharmacology , nanotechnology , medicine , biology , materials science
Invited for this month's cover picture is the group of Professor Rainer Riedl from the Institute of Chemistry and Biotechnology at the Zurich University of Applied Sciences (ZHAW), Switzerland. The cover picture depicts the structure‐based design of a drug‐like small molecule inhibitor of matrix metalloproteinase‐13 (MMP‐13) with a combined dual binding motif. The targeted introduction of a single fluoro atom was of vital importance for the optimization of the inhibitor. For more details, read the full text of the Communication at 10.1002/open.201600158.