Open AccessConformational Dynamics of DNA G‐Quadruplex in Solution Studied by Kinetic Capillary Electrophoresis Coupled On‐line with Mass Spectrometry
Author(s) -
Mironov Gleb G.,
Okhonin Victor,
Khan Nasrin,
Clouthier Christopher M.,
Berezovski Maxim V.
Publication year - 2014
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.201400004
Subject(s) - mass spectrometry , capillary electrophoresis , dna , chemistry , folding (dsp implementation) , conformational isomerism , chromatography , g quadruplex , kinetic energy , analytical chemistry (journal) , ion , physics , biochemistry , molecule , organic chemistry , quantum mechanics , electrical engineering , engineering
Invited for this months cover is the group of Prof. Maxim V. Berezovski. The cover picture shows the two‐dimensional separation of unfolded (green) and folded (red) forms of G‐quadruplex (GQ) DNA. The first dimension is kinetic capillary electrophoresis (KCE) separation of unfolded and folded DNA with different K + concentrations in solution; the second dimension is ion mobility mass spectrometry separation of DNA conformers in the gas phase. DNA folding into a compact GQ structure is mediated by K + ions. For more details, see the Full Paper on p. 58 ff.