Open AccessCover Picture: Metal‐Conjugated Affinity Labels: A New Concept to Create Enantioselective Artificial Metalloenzymes (ChemistryOpen 2/2013)
Author(s) -
Reiner Thomas,
Jantke Dominik,
Marziale Alexander N.,
Raba Andreas,
Eppinger Jörg
Publication year - 2013
Publication title -
chemistryopen
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.201390005
Subject(s) - conjugated system , moiety , chemistry , enantioselective synthesis , rhodium , stereochemistry , combinatorial chemistry , enantiomer , organic chemistry , polymer , catalysis
The cover picture illustrates the concept of using metal‐conjugated affinity labels (m‐ALs) to convert proteases into well‐defined and catalytically active artificial metalloenzymes. The X‐ray structure of the papain‐bound inhibitor E64c (orange) served as the basis to predict the orientation of the half‐sandwich rhodium(III) moiety (yellow sphere) within the binding pocket of the protease. The well‐defined position of the affinity label on the protein surface leads to a distinct environment of the metal center, which translates into enantiomeric ratios of up to 82:18 in the aqueous hydrogenation of ketones. For more details, see the Communication by Jörg Eppinger et al., on p. 50 ff.