Open AccessNon‐ATP‐Mimetic Organometallic Protein Kinase Inhibitor
Author(s) -
Wähler Kathrin,
Kräling Katja,
Steuber Holger,
Meggers Eric
Publication year - 2013
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.201300031
Subject(s) - chemistry , protein kinase a , nucleobase , biochemistry , kinase , hydrogen bond , stereochemistry , combinatorial chemistry , biophysics , biology , molecule , dna , organic chemistry
Non‐hinge binding: A novel organometallic protein kinase inhibitor scaffold based on a cyclometalated 1,8‐phenanthrolin‐7(8 H )‐one ligand is reported, which binds to the ATP binding site of the protein kinase Pim1 in an unexpected, unusual non‐ATP‐mimetic fashion without mimicking the hydrogen‐bonding interaction of the adenine nucleobase of ATP.