Rapid Microfluidic Immunoassays of Cancer Biomarker Proteins Using Disposable Inkjet‐Printed Gold Nanoparticle Arrays | Zendy

Krause Colleen E. | Zendy; Otieno Brunah A. | Zendy; Latus Alina | Zendy; Faria Ronaldo C. | Zendy; Patel Vyomesh | Zendy; Gutkind J. Silvio | Zendy; Rusling James F. | Zendy

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Rapid Microfluidic Immunoassays of Cancer Biomarker Proteins Using Disposable Inkjet‐Printed Gold Nanoparticle Arrays

Author(s) -

Krause Colleen E.,

Otieno Brunah A.,

Latus Alina,

Faria Ronaldo C.,

Patel Vyomesh,

Gutkind J. Silvio,

Rusling James F.

Publication year - 2013

Publication title -

chemistryopen

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.644

H-Index - 29

ISSN - 2191-1363

DOI - 10.1002/open.201300018

Subject(s) - microfluidics , biomarker , colloidal gold , nanotechnology , protein detection , detection limit , cancer biomarkers , materials science , magnetic nanoparticles , biosensor , nanoparticle , chemistry , cancer , chromatography , medicine , biochemistry

Off‐line amplification: A low‐cost inkjet‐printed gold nanoparticle immunoarray was integrated into a microfluidic device for multiple protein determinations. The use of heavily labeled magnetic beads allows optimization either for ultrasensitive detection of biomarker proteins (low fg mL −1 levels) or for rapid 8 min assays within clinically relevant detection ranges.

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