Photochemically Active Fluorophore–DNA/RNA Conjugates for Cellular Imaging of Nucleic Acids by Readout in Electron Microscopy | Zendy

Holzhauser Carolin | Zendy; Kracher Sabrina | Zendy; Rubner Moritz M. | Zendy; Schmucker Wolfgang | Zendy; Wagenknecht HansAchim | Zendy; Witzgall Ralph | Zendy

Open Access

Photochemically Active Fluorophore–DNA/RNA Conjugates for Cellular Imaging of Nucleic Acids by Readout in Electron Microscopy

Author(s) -

Holzhauser Carolin,

Kracher Sabrina,

Rubner Moritz M.,

Schmucker Wolfgang,

Wagenknecht HansAchim,

Witzgall Ralph

Publication year - 2013

Publication title -

chemistryopen

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.644

H-Index - 29

ISSN - 2191-1363

DOI - 10.1002/open.201300017

Subject(s) - nucleic acid , fluorophore , dna , conjugate , rna , chemistry , biophysics , microscopy , nanotechnology , fluorescence microscope , fluorescence , biochemistry , materials science , biology , physics , optics , mathematical analysis , mathematics , gene

A two‐way street: The photochemically active chromophore–nucleic acid conjugates presented herein allow not only imaging by fluorescence microscopy but additionally are able to photoinduce 3,3′‐diaminobenzidine (DAB) polymerization for staining to enable additional readout with electron microscopy.

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