Metal‐Conjugated Affinity Labels: A New Concept to Create Enantioselective Artificial Metalloenzymes | Zendy

Reiner Thomas | Zendy; Jantke Dominik | Zendy; Marziale Alexander N. | Zendy; Raba Andreas | Zendy; Eppinger Jörg | Zendy

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Metal‐Conjugated Affinity Labels: A New Concept to Create Enantioselective Artificial Metalloenzymes

Author(s) -

Reiner Thomas,

Jantke Dominik,

Marziale Alexander N.,

Raba Andreas,

Eppinger Jörg

Publication year - 2013

Publication title -

chemistryopen

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.644

H-Index - 29

ISSN - 2191-1363

DOI - 10.1002/open.201200044

Subject(s) - enantioselective synthesis , conjugated system , combinatorial chemistry , chemistry , metal , nanotechnology , organic chemistry , materials science , polymer , catalysis

How to train a protein: Metal‐conjugated affinity labels were used to selectively position catalytically active metal centers in the binding pocket of proteases. The resulting artificial metalloenzymes achieve up to 82 % e.r. in the hydrogenation of ketones. The modular setup enables a rapid generation of artificial metalloenzyme libraries, which can be adapted to a broad range of catalytic conditions.

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