Open AccessHighly Stereoselective Synthesis of Polycyclic Indoles through Rearrangement/[4+2] Cycloaddition under Sequential Catalysis
Author(s) -
Zhang DiHan,
Shi Min
Publication year - 2012
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.201200028
Subject(s) - stereoselectivity , cycloaddition , regioselectivity , chemistry , isatin , catalysis , combinatorial chemistry , stereochemistry , cascade reaction , organic chemistry
Cascade transformation: A highly regioselective and stereoselective synthesis of polyfunctional indoles from isatin derivatives and allenic esters is disclosed. The novel cascade transformation is a direct and rapid entry to polycyclic indoles through sequential catalysis of rearrangement and [4+2] cycloaddition under very mild conditions bearing various substituents at many positions.