Open AccessA Platform for Specific Delivery of Lanthanide–Scandium Mixed‐Metal Cluster Fullerenes into Target Cells
Author(s) -
Svitova Anna,
Braun Klaus,
Popov Alexey A.,
Dunsch Lothar
Publication year - 2012
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.201200023
Subject(s) - scandium , lanthanide , fullerene , cluster (spacecraft) , nanotechnology , metal , materials science , chemistry , inorganic chemistry , computer science , organic chemistry , metallurgy , ion , programming language
A shuttle into cells: A modular c‐myc‐antisense‐Gd@BioShuttle system (see figure), comprising a gadolinium‐ containing nitride cluster fullerene as an imaging component, an address module (nuclear localization sequence) and a transmembrane carrier peptide, is prepared, and its facile intracellular localization is proven by in vitro studies.