Direct Catalytic Asymmetric Synthesis of Pyrazolidine Derivatives | Zendy

Deiana Luca | Zendy; Zhao GuiLing | Zendy; Leijonmarck Hans | Zendy; Sun Junliang | Zendy; Lehmann Christian W. | Zendy; Córdova Armando | Zendy

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Direct Catalytic Asymmetric Synthesis of Pyrazolidine Derivatives

Author(s) -

Deiana Luca,

Zhao GuiLing,

Leijonmarck Hans,

Sun Junliang,

Lehmann Christian W.,

Córdova Armando

Publication year - 2012

Publication title -

chemistryopen

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.644

H-Index - 29

ISSN - 2191-1363

DOI - 10.1002/open.201200015

Subject(s) - enantioselective synthesis , chemistry , pyrazoline , combinatorial chemistry , nitrile , catalysis , cycloaddition , michael reaction , organic chemistry

Simple yet effective: A highly enantioselective, metal‐free cascade reaction between di‐1,2‐ N ‐protected hydrazine and α,β‐unsaturated aldehydes is disclosed. The catalytic, asymmetric cascade transformation is a direct entry to 3‐hydroxypyrazolidine and 3‐allylpyrazolidine derivatives in one step and two steps, respectively, with >19:1 d.r. and 98–99 % ee using simple chiral pyrrolidines as catalysts.

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