Open AccessDual Enzyme‐Triggered Controlled Release on Capped Nanometric Silica Mesoporous Supports
Author(s) -
Agostini Alessandro,
Mondragón Laura,
Coll Carmen,
Aznar Elena,
Marcos M. Dolores,
MartínezMáñez Ramón,
Sancenón Félix,
Soto Juan,
PérezPayá Enrique,
Amorós Pedro
Publication year - 2012
Publication title -
chemistryopen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 29
ISSN - 2191-1363
DOI - 10.1002/open.201200003
Subject(s) - amidase , urease , mesoporous material , mesoporous silica , urea , chemistry , amide , nanoparticle , combinatorial chemistry , chemical engineering , dual (grammatical number) , enzyme , nanotechnology , organic chemistry , polymer chemistry , materials science , catalysis , art , literature , engineering
Please release me: Mesoporous silica nanoparticles capped with bulky organic moieties containing amide and urea linkages were able to release their cargo upon addition of amidase and urease. Amidase induced an immediate, yet not complete, release of the cargo. On the other hand, urease allowed a near total cargo release that was delayed in time (see graph).