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Mass spectrometry of some 10β‐Fluoro‐1,4‐estradien‐3‐oxo steroids
Author(s) -
Desmarteau D. D.,
Resnati G.,
Seraglia R.,
Traldi P.
Publication year - 1994
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210290107
Subject(s) - fragmentation (computing) , chemistry , moiety , fluorine , kinetic energy , mass spectrometry , ion , electron ionization , ring (chemistry) , ionization , cleavage (geology) , fast atom bombardment , computational chemistry , analytical chemistry (journal) , medicinal chemistry , stereochemistry , organic chemistry , chromatography , materials science , physics , quantum mechanics , fracture (geology) , computer science , composite material , operating system
The mass spectrometric behavior of some 10β‐fluoro‐1,4‐estradiene‐3‐oxo steroids under two different ionization conditions (electron inpact and fast atom bombardment) was studied with the aid of mass‐analyzed ion kinetic energy spectroscopy. The influence of fluorine in the fragmentation pattern was investigated by comparison with the behavior of 10‐methyl analogs. In particular, the presence of fluorine at position 10 seems to reflect the weakening of C(9)C(10) bond. Further, when an acyloxy moiety is present at position 17, the primary ring cleavages typical of steroids become disfavored and fragment ions related to the acyloxy substituents are detected.