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Ion–molecule reactions and dissociation of glycols in a quadrupole ion trap mass spectrometer: Evidence of intramolecular interactions
Author(s) -
Eichmann Erika S.,
Brodbelt Jennifer S.
Publication year - 1993
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210280703
Subject(s) - chemistry , intramolecular force , dissociation (chemistry) , ion , fragmentation (computing) , deuterium , methylene , molecule , quadrupole ion trap , mass spectrometry , mass spectrum , photochemistry , ion trap , ether , medicinal chemistry , organic chemistry , physics , chromatography , quantum mechanics , computer science , operating system
Polyethylene glycols react with CH 3 OCH 2 + ions from dimethyl ether to form [M + 13] + products. The [M + 13] + ions are stabilized by intramolecular interactions involving the internal ether oxygen atoms and the terminal methylene group. Collisionally activated dissociation (CAD), including MS n and deuterium labeling experiments show that fragmentation reactions involving intramolecular cyclization are predominant. Scrambling of hydrogen and deuterium atoms in the ion‐molecule reaction products is not indicated. The CAD spectra of the [M + 13] + ions provide unambiguous assignment of the glycol size.