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A new ion source for liquid chromatography/thermospray mass spectrometry with a magnetic sector field mass spectrometer
Author(s) -
Hau J.,
Nigge W.,
Linscheid M.
Publication year - 1993
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210280314
Subject(s) - thermospray , mass spectrometry , chemistry , ion source , analytical chemistry (journal) , fragmentation (computing) , chromatography , ion , ion mobility spectrometry , hybrid mass spectrometer , tandem mass spectrometry , selected reaction monitoring , organic chemistry , computer science , operating system
A new and simple ion source for thermospray on a sector field mass spectrometer has been designed, which is based on two sets of electrostatic quadrupole lenses to focus the divergent ion beam that emanates from the extraction cone into the ion source region. To illustrate the performance of the source, the on‐line separation and detection of a few samples are shown using scanning and single‐ion monitoring techniques. Examples are a mixture of phena‐zines and samples of caffeine and adenosine. With single ion motoring, 5 ng of a phenazine, 300 pg of caffeine and ∼1 ng of adenosine were detected. Further, it is shown that declustering and collision‐induced fragmentation occur inside the sampling cone, resulting in peak broadening on the low‐mass side of signals of protonated species. Minimizing the collision‐induced dissociation of erythromycin was used to optimize the flow‐rate of the liquid chromatograph and the pressure in the source housing.