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Comparison by mass spectrometry of ring cleavage in barbituric acid and 5‐fluorobarbituric acid derivatives
Author(s) -
Desmarteau Darryl D.,
Resnati Giuseppe,
Favretto Donata,
Traldi Pietro
Publication year - 1992
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210270309
Subject(s) - barbituric acid , chemistry , fragmentation (computing) , ring (chemistry) , fast atom bombardment , fluorine , mass spectrometry , alkyl , bond cleavage , electron ionization , cleavage (geology) , ion , ionization , medicinal chemistry , organic chemistry , chromatography , catalysis , geotechnical engineering , fracture (geology) , computer science , engineering , operating system
The mass spectrometric behaviour of barbituric acid and 1,3‐dimethylbarbituric acid was compared with that of the corresponding 5,5‐difluoro derivatives and of some 5‐fluoro‐5‐alkyl derivatives in order to study the influence of fluorine in the fragmentation processes. This investigation, performed using both electron impact ionization and positive‐ and negative‐ion fast atom bombardment, evidences well the role of fluorine in barbiturate ring bond cleavages.