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Detection of fragment ions produced by collisional activation of multiply charged ions in a floated collision cell
Author(s) -
Orlando Ron,
Boyd R. K.
Publication year - 1992
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210270216
Subject(s) - ion , atomic physics , collision , spectrometer , mass spectrometry , chemistry , charge (physics) , fragment (logic) , tandem mass spectrometry , tandem , physics , materials science , chromatography , programming language , computer security , organic chemistry , quantum mechanics , computer science , composite material
A scan law is derived for the detection of fragment ions formed by collisional activation (CA) of a multiply charged precursor in a floated collision cell of a tandem mass spectrometer. Comparisons of the CA spectra of multiply charged ions obtained in either a floated or a grounded collision cell demonstrate the benefits associated with raising the collision cell above ground potential. In addition to the advantages observed for singly charged ions, floating the collision cell increases the transmission of multiply charged ions through the first mass spectrometer by permitting higher source potentials to be used. This technique also increases the detection efficiency for products of charge separation reactions, which may prove useful in the charge state assignment of the fragment ions.