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A study of some imidazo[l,5‐ a ]benzodiazepin‐6‐ones by electron impact mass spectrometry. characterization by tandem mass spectrometry of a distonic fragment ion
Author(s) -
Rubino Federico Maria,
Zecca Luigi,
Mascaro Paolo,
Hunkeler Walter
Publication year - 1991
Publication title -
organic mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0030-493X
DOI - 10.1002/oms.1210260705
Subject(s) - chemistry , tandem mass spectrometry , mass spectrometry , tandem , ion , electron ionization , isomerization , metastability , mass spectrum , analytical chemistry (journal) , protein mass spectrometry , selected reaction monitoring , top down proteomics , computational chemistry , chromatography , organic chemistry , materials science , ionization , composite material , catalysis
The mass spectra of several imidazo[l,5‐ a ]benzodiazepin‐6‐one derivatives of neuropharmacological significance were determined in order to establish their decomposition paths under electron impact. A novel distonic fragment ion was observed and it was possible to demonstrate by consideration of metastable ions and by tandem mass spectrometry that it undergoes isomerization to the corresponding classical structure.